Known unknowns

  • What happens at the singularity in a Black Hole
  • Why the parameterization of the universe (e.g. Planck’s constant) seem tuned for us to exist
  • What in the brain explains the ‘hard problem’ of consciousness
  • Why plant phospholipid metabolism is so different from animals or yeast
  • The proto-function of the ribosome before proteins came on the scene
  • Before the Big Bang
  • Fermi’s paradox
  • When will the next pandemic hit
  • Will humans persist into the 22nd century