A man with a plan: Henry Markram and his Human Brain Project, in an excellent piece here by Nature’s Mitch Waldrop.
Henry is a difficult read. On the one hand, he’s Teddy Roosevelt to the Panama Canal. On the other he’s possibly Don Quixote charging at some windmills. I can’t tell yet and I don’t think Mitch knows either. But either way, Markram does recognize a key weakness of modern neuroscience: it lacks the coherent theoretical framework that other lucky fields have (such as the standard model in physics).