I rarely delve into the day to day here at the Institute, but, mostly to give a flavor of the scientific program, here goes:
Please join us for the next Krasnow Monday Seminar TODAY
Refreshments will be served at 3:30pm. Come chat with colleagues and like-minded researchers and students prior to the talk at 4pm.
SPEAKER: Iosif Vaisman,
Professor and Director of the Ph.D. Program,
Department of Bioinformatics and Computational Biology,
George Mason University
Protein function analysis using computational mutagenesis:
Proteins exhibit a wide range of functional consequences upon mutation.
Accurate predictive models for the impact of single amino acid
substitutions on protein stability and activity provide important insights
into protein structure and function. Such models are also valuable for the
design and engineering of new proteins. This talk will focus on a
computational mutagenesis technique based on a four-body, knowledge-based,
statistical contact potential and machine learning methods. For any
mutation due to a single amino acid replacement in a protein, the method
provides an empirical normalized measure of the ensuing environmental
perturbation occurring at every residue position. The predictive
mutagenesis models are evaluated using large training sets of mutants
derived from diverse proteins that have been experimentally studied and
described. These predictive models are either comparable to, or in many
cases signicantly outperform, alternative approaches.
Hat tip to Carolyn Payne and our support staff…