So what’s the deal with confocal microscopy? The short version goes like this: biological specimens, especially living tissue ones, are thick. Classical microscopes have a problem with this and internal organelles get blurred out. With confocal microscopy, we can get around that problem and look into the sample with all the detail of the cell’s three-dimensional structure preserved. Used in consort with our ability to molecularly engineer biological components of the cell to fluoresce, this becomes an incredibly powerful tool for our neuroscientists who work at the neuronal or cellular level.